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CAS No. 84625-61-6 | Itraconazole

Name: Itraconazole CAS No. 84625-61-6 MF:C35H38Cl2N8O4 MW:705.63 Purity:98% Package: 5g,25g,200g,500g,1kg Worldwide Delivery

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Product introduction

Introduction and application of CAS No. 84625-61-6 | Itraconazole

Synonyms:

4-[4-[4-[4-[[2-(2，4-Dichlomphenyl)-2-(1H-1，2，4-tfiazol-1-yl-methyl)-1,3-dioxolan-4-y1]methoxyl]phenyl]-1-piperazinyl]phenyl]-2，4-dihydro-2-(1-methylpropyl)-3H-1，2，4-triazol-3-one;Oricomzole;

3H-1,2,4-Triazol-3-one,4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-;

4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(1-methylpropyl)-2,4-dihydro-1,2,4-triazol-3-one

Specification:

ITEMS	SPECIFICATION
CAS	84625-61-6
MF	C35H38Cl2N8O4
MW	705.63
Melting point	166°C
Boiling point	850.0±75.0 °C
Density	1.27 g/cm3
Acidity coefficient	3.7(at 25℃)
Color	White
Solubility	Chloroform: 50 mg/mL, clear, colorless
Form	Powder
Storage condition	2-8°C

Itraconazole is a synthetic triazole derivative. It is a synthetic broad-spectrum antifungal drug. Its antibacterial spectrum and antibacterial mechanism are similar to clotrimazole, but it has strong antibacterial activity against Aspergillus. By changing The permeability of the fungal cell membrane exerts antibacterial activity, and it has antibacterial activity against pathogenic bacteria in superficial and deep fungal infections. Its antibacterial spectrum is broader and stronger than ketoconazole, and it can inhibit the synthesis of ergosterol in the fungal cell membrane, thus exerting antifungal effects.

use:

Synthetic azole broad-spectrum antifungal drugs are used for systemic infections caused by deep fungi, and can also be used for candidiasis and aspergillosis.

production method:

Starting from m-dichlorobenzene, compound (I) can be obtained through a reaction completely similar to ketoconazole. Compound (Ⅰ) is then condensed with 1-acetyl-4-(4-hydroxyphenyl)piperazine, then hydrolyzed to remove the acetyl group, condensed with p-nitrochlorobenzene, hydrogenated and reduced, acylated with chloroformate, and then It reacts with hydrazine hydrate and then undergoes cyclization and alkylation to obtain itraconazole. The intermediate 1-acetyl-4-(4-hydroxyphenyl)piperazine can be prepared through the following reaction using piperazine as raw material.

Package and transportation :

Package: 5g,25g,200g,500g,1kg